: All known life requires phosphorus (P) in the form of inorganic phosphate (PO43x or Pi) and phosphate-containing organic molecules. Pi serves as the backbone of the nucleic acids that constitute genetic material and as the major repository of chemical energy for metabolism in polyphosphate bonds. Arsenic (As) lies directly below P on the periodic table and so the two elements share many chemical properties, although their chemistries are sufficiently dissimilar that As cannot directly replace P in modern biochemistry. Arsenic (...) is toxic because As and P are similar enough that organisms attempt this substitution. We hypothesize that ancient biochemical systems, analogous to but distinct from those known today, could have utilized arsenate in the equivalent biological role as phosphate. Organisms utilizing such ‘ weird life ’ biochemical pathways may have supported a ‘ shadow biosphere ’ at the time of the origin and early evolution of life on Earth or on other planets. Such organisms may even persist on Earth today, undetected, in unusual niches. (shrink)

Institutional review boards are almost universally considered to be overworked and understaffed. They also require substantial commitments of time and resources from their members. Although some surveys report average IRB memberships of 15 people or more, federal regulations require only five. We present data on IRB meetings at eight of the top 25 academic medical centers in the United States funded by the National Institutes of Health. These data indicate substantial contributions from primary reviewers and chairs during protocol discussions but (...) little from other members, which implies that it may be possible for smaller IRBs to accomplish the same tasks with no reduction in the quality of review. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Slipping on Banana Peels, Tumbling into WellsPhilosophy and ComedyPaul A. Kottman (bio)Alenka Zupančič. The Odd One In: On Comedy. Cambridge, MA: MIT P, 2008.[T]he philosopher... is the jest, not only of Thracian handmaids but of the general herd, tumbling into wells and every sort of disaster through his inexperience [hupo apeirias].—Plato, Theaetetus 174cWhy stop philosophy’s most precious intrinsic comedy when it comes to comedy?—Alenka Zupančič, The Odd One In1“Comedy,” (...) writes Alenka Zupančič in The Odd One In, “draws our attention to the fact that something of our life lives on its own as we speak, that is to say, at any moment of our life” [218]. Reelaborating some of Jacques Lacan’s formulations regarding comedy, drive, and desire, Zupančič clarifies that this “something” is the “Real of human desire”— namely, “the incongruence of the reality of desire and drive with all those (also quite factual) outlines that determine our supposedly realistic reality” [218]. This extrapolation from Lacan frames Zupančič’s views on comedy and its subversive character; but it is her unique engagement with G. W. F. Hegel’s remarks on comedy—particularly the sections of the Phenomenology of Spirit in which Hegel tracks the passage from the Comedy of Aristophanes to Christianity—that give a distinctive arc to Zupančič’s highly original and generative approach to comedy and its subversive character. In this review essay, I will draw attention to some of the most original aspects of this critical appropriation of Hegel, while highlighting key elements of the text’s argumentative trajectory. Toward the end of this essay, I will also suggest ways that Hegel’s speculative remarks, which see the comic figure as symptomatic of a community that is not yet conscious of itself as such, might allow us to put into question some of Zupančič’s central claims regarding the subversive nature of both comedy and her own critical intervention.Zupančič’s reflections on comedy—which are not only innovative, but also delightfully readable—merit, in their own right, the attention of anyone interested in the intersection of literature, philosophy, and contemporary culture; but her text is all the more significant in light of the oft-remarked rarity of sustained philosophical reflections on comedy. Although there are a number of books on comedy as a literary genre, philosophical studies of comedy are surprisingly rare.1 Henri Bergson’s Le rire (published in 1900) [End Page 3] is perhaps the most well known. More recently, Simon Critchley has written about laughter, wit, and jokes in On Humour. Perhaps the most comprehensive philosophical account of comedy to date—Agnes Heller’s Immortal Comedy: The Comic Phenomenon in Art, Literature and Life (2005)—was published only three years before The Odd One In.2In contrast to Heller’s work, which offers a philosophical account of a variety of comic works and genres, and unlike these other earlier studies, which deal with the poetics of comedy and related phenomena such as laughter or jokes, Zupančič does not approach comedy as an object of inquiry that might be analyzed by philosophical categories or methods, nor even as a phenomenon that is extrinsic to philosophy. Instead, she sees comedy and philosophy as intrinsic to one another, such that the fate of philosophical activity is tied to the fate of the comical. In assessing Zupančič’s claims, therefore, I will strive less for a summary catalogue of the claims presented in the book than for a reelaboration of what I take to be her most provocative and important assertions regarding what she calls the “critical edge” shared by both philosophy and comedy [Zupančič 9].The Odd One In is the eighth title in the series Short Circuits, edited by Slavoj Žižek, in relation to whose writings Zupančič’s text clearly stands in intellectual and stylistic propinquity. (Žižek himself might be taken as a prime figure in whom comic and philosophical practices, in Zupančič’s sense, coincide.) The book opens and closes with a reminder that we too often mistake the subversive side of comedy for “a consolation... (shrink)

Ce recueil d’études sur Vatican II, par un observateur attentif et passionné de l’événement conciliaire, reprend des textes antérieurs retravaillés ou traduits en français et publie quatre inédits: sur les amendements de Paul VI à propos du mariage dans Gaudium et spes, et sur des personnalités belges et hollandaises, notamment sur la part prise par W. Onclin à la rédaction de Christus Dominus et sur l’action prophétique, vigilante et tenace du cardinal J. Willebrands. Il s’impose à ceux qui s’intéressent (...) à l’histoire du concile et suggère bien des pistes pour des recherches ultérieures. (shrink)

In this strikingly original work, Paul W. Kahn rethinks the meaning of political theology. In a text innovative in both form and substance, he describes an American political theology as a secular inquiry into ultimate meanings sustaining our faith in the popular sovereign. Kahn works out his view through an engagement with Carl Schmitt's 1922 classic, _Political Theology: Four Chapters on the Concept of Sovereignty_. He forces an engagement with Schmitt's four chapters, offering a new version of each that (...) is responsive to the American political imaginary. The result is a contemporary political theology. As in Schmitt's work, sovereignty remains central, yet Kahn shows how popular sovereignty creates an ethos of sacrifice in the modern state. Turning to law, Kahn demonstrates how the line between exception and judicial decision is not as sharp as Schmitt led us to believe. He reminds readers that American political life begins with the revolutionary willingness to sacrifice and that both sacrifice and law continue to ground the American political imagination. Kahn offers a political theology that has at its center the practice of freedom realized in political decisions, legal judgments, and finally in philosophical inquiry itself. (shrink)

At his death in 1987, Paul W. Pruyser of the Menninger Foundation was widely recognized as one of America's foremost authorities on the psychology of religion. His book A Dynamic Psychology of Religion set the stage for creative dialogue on the subject. In this volume, two leading practitioners in the field present a compilation of Pruyser's seminal articles, providing an overview of the major themes in Pruyser's thought. Newton Malony and Bernard Spilka evaluate Pruyser's viewpoint and suggest how his (...) position continues to influence the psychology of religion. (shrink)

Gene Spitler has raised certain objections to my views on the biocentric outlook: (1) that a factual error is involved in the assertion that organisms pursue their own good, (2) that there is an inconsistency in the biocentric outlook, (3) that it is impossible for anyone to adopt that outlook, and (4) that the outlook entails unacceptable moral judgments, for example, that killing insects and wildfiowers is as morally reprehensible as killing humans. I reply to each of these points, showing (...) that the biocentric outlook on nature is not only a possible, but also a reasonable world view. (shrink)

In this wide-ranging interdisciplinary work, Paul W. Kahn argues that political order is founded not on contract but on sacrifice. Because liberalism is blind to sacrifice, it is unable to explain how the modern state has brought us to both the rule of law and the edge of nuclear annihilation. We can understand this modern condition only by recognizing that any political community, even a liberal one, is bound together by faith, love, and identity.Putting Liberalism in Its Place draws (...) on philosophy, cultural theory, American constitutional law, religious and literary studies, and political psychology to advance political theory. It makes original contributions in all these fields. Not since Charles Taylor's The Sources of the Self has there been such an ambitious and sweeping examination of the deep structure of the modern conception of the self.Kahn shows that only when we move beyond liberalism's categories of reason and interest to a Judeo-Christian concept of love can we comprehend the modern self. Love is the foundation of a world of objective meaning, one form of which is the political community. Arguing from these insights, Kahn offers a new reading of the liberalism/communitarian debate, a genealogy of American liberalism, an exploration of the romantic and the pornographic, a new theory of the will, and a refoundation of political theory on the possibility of sacrifice.Approaching politics from the perspective of sacrifice allows us to understand the character of twentieth-century politics, which combined progress in the rule of law with massive slaughter for the state. Equally important, this work speaks to the most important political conflicts in the world today. It explains why American response to September 11 has taken the form of war, and why, for the most part, Europeans have been reluctant to follow the Americans in their pursuit of a violent, sacrificial politics. Kahn shows us that the United States has maintained a vibrant politics of modernity, while Europe is moving into a postmodern form of the political that has turned away from the idea of sacrifice. Together with its companion volume, Out of Eden, Putting Liberalism in Its Place finally answers Clifford Geertz's call for a political theology of modernity. (shrink)

_An examination of how two fundamental concepts of order influence our ideas about sovereignty, citizenship, law, and history_ Western accounts of natural and political order have deployed two basic ideas: project and system. In a project, order is produced by the intentional act of a subject; in a system, order is immanent in the world. In the former, order is made; in the latter, discovered. Paul W. Kahn shows how project and system have long been at work in our (...) theological and philosophical tradition. Against this background, Kahn explains the development of the modern legal imagination in the nineteenth century as a movement from project to system. Americans began the century imagining the constitutional order as their common project: a deliberate construction of We the People. They ended the century imagining that order is continuous with the common law: an immanent development of the principles of civilization. This imaginative shift affected ideas of legal text, sovereignty, citizenship, interpretation, history, and science. (shrink)

Paul and Religion demonstrates the continuing and contemporary relevance of the most important, and most controversial, figure of early Christianity. Paul Gooch interrogates the Pauline writings for their meaning as well as implications for religion as an entire form of life, a stance on the world expressed in distinctive practices. Bringing a philosophical approach to this topic, he connects Paul's ideas to lived experience. In a conversational style, Gooch explores Paul's experience of grace and his dismissal (...) of distinctive markers of religious identity in favour of love as binding together a community. Contrary to common expectations, he finds within Paul's letters material for conversations about issues in our day, such as gender and sexuality. From his close reading of the Letters, Gooch argues that the Pauline religious form of life is not identical with institutional Christianity. Indeed, his conclusions may be welcome to those who belong to other faiths. (shrink)

What rational justification is there for conceiving of all living things as possessing inherent worth? In _Respect for Nature_, Paul Taylor draws on biology, moral philosophy, and environmental science to defend a biocentric environmental ethic in which all life has value. Without making claims for the moral rights of plants and animals, he offers a reasoned alternative to the prevailing anthropocentric view--that the natural environment and its wildlife are valued only as objects for human use or enjoyment. _Respect for (...) Nature_ provides both a full account of the biological conditions for life--human or otherwise--and a comprehensive view of the complex relationship between human beings and the whole of nature. This classic book remains a valuable resource for philosophers, biologists, and environmentalists alike--along with all those who care about the future of life on Earth. A new foreword by Dale Jamieson looks at how the original 1986 edition of _Respect for Nature_ has shaped the study of environmental ethics, and shows why the work remains relevant to debates today. (shrink)

Aristotle argued that citizenship is like friendship, and this book applies his argument to modern society. Modern citizens may lack the concept of civic friendship, but they persist in many practices and passions that were once considered essential to it. Citizens share many similarities with friends: prejudices held in common, favoritism towards each other, and - despite disagreement on specifics - underlying agreement about what is important, such as freedom and equality. Aristotle's theory reminds us that civic friendship is a (...) factual condition of healthy societies, not a pie-in-the-sky ideal. By recognizing when it occurs and understanding it, we can build on it to counteract societal polarization. Civic friendship offers an alternative to populism and nationalism by engaging some of the same passions. In an era increasingly marked by tribalism and identity politics, this timely study will be of interest to a wide range of readers in political science, classics, and philosophy. (shrink)

The first comprehensive study of the roots of the concept of genius in Kant's understanding of nature and his notion of the artist.

Course Correction engages in deliberation about what the twenty-first-century university needs to do in order to re-find its focus as a protected place for unfettered commitment to knowledge, not just as a space for creating employment or economic prosperity. The university's business, Paul W. Gooch writes, is to generate and critique knowledge claims, and to transmit and certify the acquisition of knowledge. In order to achieve this, a university must have a reputation for integrity and trustworthiness, and this, in (...) turn, requires a diligent and respectful level of autonomy from state, religion, and other powerful influences. It also requires embracing the challenges of academic freedom and the effective governance of an academic community. Course Correction raises three important questions about the twenty-first-century university. In discussing the dominant attention to student experience, the book asks, "Is it now all about students?" Secondly, in questioning "What knowledge should undergraduates gain?" it provides a critique of undergraduate experience, advocating a Socratic approach to education as interrogative conversation. Finally, by asking "What and where are well-placed universities?" the book makes the case against placeless education offered in the digital world, in favour of education that takes account of its place in time and space. (shrink)

By drawing on the writings of both Jungian and psychoanalytic thinkers as well as on poetry, mythology and art, and by illustrating these ideas with dreams and ...

1 Adaptationism is a research strategy that seeks to identify adaptations and the specific selective forces that drove their evolution in past environments. Since the mid-1970s, paleontologist Stephen J. Gould and geneticist Richard Lewontin have been critical of adaptationism, especially as applied toward understanding human behavior and cognition. Perhaps the most prominent criticism they made was that adaptationist explanations were analogous to Rudyard Kipling's Just So Stories. Since storytelling is an inherent part of science, the criticism refers to the acceptance (...) of stories without sufficient empirical evidence. In particular, Gould, Lewontin, and their colleagues argue that adaptationists often use inappropriate evidentiary standards for identifying adaptations and their functions, and that they often fail to consider alternative hypotheses to adaptation. Playing prominently in both of these criticisms are the concepts of constraint, spandrel, and exaptation. In this article we discuss the standards of evidence that could be used to identify adaptations and when and how they may be appropriately used. Moreover, building an empirical case that certain features of a trait are best explained by exaptation, spandrel, or constraint requires demonstrating that the trait's features cannot be better accounted for by adaptationist hypotheses. Thus, we argue that the testing of alternatives requires the consideration, testing, and systematic rejection of adaptationist hypotheses. Where possible, we illustrate our points with examples taken from human behavior and cognition. Key Words: adaptation; ADHD; brain allometry; constraint; epistemology; evolutionary psychology; exaptation; female orgasm ; optimization; special design; waist-hip ratio. Footnotes1 The authors contributed equally to this paper. Order of authorship was determined alphabetically. Correspondence may be addressed to any of the authors. (shrink)

In this work, the first overview of the German Idealism that is both conceptual and methodological, Paul W. Franks offers a philosophical reconstruction that is...

Louis G. Lombardi’s arguments in support of the claim that humans have greater inherent worth than other living things provide a clear account of how it is possible to conceive of the relation between humans and nonhumans in this way. Upon examining his arguments, however, it seems that he does not succeed in establishing any reason to believe that humans actually do have greater inherent worth than animals and plants.